LMPD Database

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LMP007046

UniProt Annotations

Entry Information
Gene Namesphingosine N-acyltransferase LAC1
Protein EntryLAC1_YEAST
UniProt IDP28496
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + sphingosine = CoA + N- acylsphingosine.
FunctionComponent of the ceramide synthase complex required for C26-CoA-dependent ceramide synthesis. Redundant with LAG1. Facilitates ER-to-Golgi transport of GPI-anchored proteins. {ECO:0000269|PubMed:10198056, ECO:0000269|PubMed:11387200, ECO:0000269|PubMed:11694577, ECO:0000269|PubMed:15692566}.
InductionExpression is controlled by PDR1 and PDR3 which bind its propmoter PDRE element, and by ROX1 and CBF1
InductionExpression is controlled by PDR1 and PDR3 which bind its propmoter PDRE element, and by ROX1 and CBF1. {ECO:0000269|PubMed:15302821}.
InteractionP38703:LAG1; NbExp=7; IntAct=EBI-26585, EBI-10035; Q03579:LIP1; NbExp=6; IntAct=EBI-26585, EBI-27640;
MiscellaneousPresent with 2840 molecules/cell in log phase SD medium
MiscellaneousPresent with 2840 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the sphingosine N-acyltransferase family
SimilarityBelongs to the sphingosine N-acyltransferase family. {ECO:0000305}.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:10198056, ECO:0000269|PubMed:14562095}; Multi- pass membrane protein {ECO:0000269|PubMed:10198056, ECO:0000269|PubMed:14562095}.
Subcellular LocationEndoplasmic reticulum membrane ; Multi- pass membrane protein {ECO:0000269|PubMed:10198056, ECO:0000269|PubMed:14562095}.
SubunitComposed of the ceramide synthase complex composed of at least LAC1, LAG1 and LIP1.