LMPD Database

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LMP007054

UniProt Annotations

Entry Information
Gene NameEgd2p
Protein EntryNACA_YEAST
UniProt IDP38879
SpeciesYeast (S288c)
Comments
Comment typeDescription
DomainThe UBA domain is required for the stability of EGD1.
FunctionComponent of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation. {ECO:0000269|PubMed:10219998, ECO:0000269|PubMed:10512867, ECO:0000269|PubMed:10518932, ECO:0000269|PubMed:11959135, ECO:0000269|PubMed:16926149, ECO:0000269|PubMed:9482879}.
InteractionQ02642:EGD1; NbExp=7; IntAct=EBI-6379, EBI-6371; P10664:RPL4A; NbExp=2; IntAct=EBI-6379, EBI-15390; P15731:UBC4; NbExp=2; IntAct=EBI-6379, EBI-19735;
MiscellaneousPresent with 38016 molecules/cell in log phase SD medium
MiscellaneousPresent with 38016 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmUbiquitinated by the NOT4 E3 ligase and the UBC4 E2 ubiquitin conjugatin enzyme
PtmUbiquitinated by the NOT4 E3 ligase and the UBC4 E2 ubiquitin conjugatin enzyme. {ECO:0000269|PubMed:16926149}.
SimilarityBelongs to the NAC-alpha family
SimilarityBelongs to the NAC-alpha family. {ECO:0000305}.
SimilarityContains 1 NAC-A/B (NAC-alpha/beta) domain
SimilarityContains 1 NAC-A/B (NAC-alpha/beta) domain. {ECO:0000255|PROSITE-ProRule:PRU00507}.
SimilarityContains 1 UBA domain
SimilarityContains 1 UBA domain. {ECO:0000305}.
Subcellular LocationCytoplasm. Nucleus. Note=Predominantly cytoplasmic, may also transiently localize to the nucleus. Nuclear import may occur via redundant pathways including one requiring the karyopherins PSE1 and KAP123, which also participate in nuclear import of ribosomal subunits.
SubunitPart of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and either EGD1 or BTT1. NAC associates with ribosomes via EGD1 or BTT1, and with the CCR4-NOT complex.