LMPD Database

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LMP007156

UniProt Annotations

Entry Information
Gene NameOrm2p
Protein EntryORM2_YEAST
UniProt IDQ06144
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionComponent of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis. Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity. {ECO:0000269|PubMed:20182505}.
InteractionSelf; NbExp=1; IntAct=EBI-34916, EBI-34916; P25376:AGP1; NbExp=1; IntAct=EBI-34916, EBI-2357; P36039:AIM27; NbExp=1; IntAct=EBI-34916, EBI-27005; P38626:CBR1; NbExp=1; IntAct=EBI-34916, EBI-2048224; Q12127:CCW12; NbExp=1; IntAct=EBI-34916, EBI-5303; P08456:CHO1; NbExp=1; IntAct=EBI-34916, EBI-14055; Q05031:DFG5; NbExp=1; IntAct=EBI-34916, EBI-27512; P39540:ELO1; NbExp=1; IntAct=EBI-34916, EBI-2049096; P47133:EMC2; NbExp=1; IntAct=EBI-34916, EBI-25568; P53045:ERG25; NbExp=1; IntAct=EBI-34916, EBI-6506; P53199:ERG26; NbExp=1; IntAct=EBI-34916, EBI-6514; Q05359:ERP1; NbExp=1; IntAct=EBI-34916, EBI-6581; P39704:ERP2; NbExp=1; IntAct=EBI-34916, EBI-6587; Q12450:ERP4; NbExp=1; IntAct=EBI-34916, EBI-6598; P54837:ERV25; NbExp=1; IntAct=EBI-34916, EBI-6642; P19145:GAP1; NbExp=1; IntAct=EBI-34916, EBI-7314; Q07830:GPI13; NbExp=1; IntAct=EBI-34916, EBI-32339; Q04697:GSF2; NbExp=1; IntAct=EBI-34916, EBI-27807; P40499:ICE2; NbExp=1; IntAct=EBI-34916, EBI-25109; P40006:IRC22; NbExp=1; IntAct=EBI-34916, EBI-2050819; P38250:IST2; NbExp=1; IntAct=EBI-34916, EBI-21520; P40540:KRE27; NbExp=1; IntAct=EBI-34916, EBI-24977; P38694:MSC7; NbExp=1; IntAct=EBI-34916, EBI-24511; P32500:NDC1; NbExp=1; IntAct=EBI-34916, EBI-11950; P53224:ORM1; NbExp=1; IntAct=EBI-34916, EBI-12592; P41543:OST1; NbExp=1; IntAct=EBI-34916, EBI-12651; Q12144:PER33; NbExp=1; IntAct=EBI-34916, EBI-37691; P38264:PHO88; NbExp=1; IntAct=EBI-34916, EBI-13350; P40857:PHS1; NbExp=1; IntAct=EBI-34916, EBI-26003; P40975:PMP2; NbExp=1; IntAct=EBI-34916, EBI-2043041; P87284:PMP3; NbExp=1; IntAct=EBI-34916, EBI-13555; Q04947:RTN1; NbExp=1; IntAct=EBI-34916, EBI-38020; P32368:SAC1; NbExp=1; IntAct=EBI-34916, EBI-16210; P14906:SEC63; NbExp=1; IntAct=EBI-34916, EBI-16636; Q02774:SHR3; NbExp=1; IntAct=EBI-34916, EBI-17099; P39543:SOP4; NbExp=1; IntAct=EBI-34916, EBI-26193; P46965:SPC1; NbExp=1; IntAct=EBI-34916, EBI-17823; Q04969:SPC2; NbExp=1; IntAct=EBI-34916, EBI-27827; P39986:SPF1; NbExp=1; IntAct=EBI-34916, EBI-3128; P38353:SSH1; NbExp=1; IntAct=EBI-34916, EBI-18175; Q02795:SWP1; NbExp=1; IntAct=EBI-34916, EBI-12666; Q08438:VHS3; NbExp=1; IntAct=EBI-34916, EBI-30482; P33767:WBP1; NbExp=1; IntAct=EBI-34916, EBI-12658; Q3E6R4:YDR524C-B; NbExp=1; IntAct=EBI-34916, EBI-2047890; Q3E7B0:YER053C-A; NbExp=1; IntAct=EBI-34916, EBI-2047907; P38845:YHR146W; NbExp=1; IntAct=EBI-34916, EBI-24770; P53872:YNL190W; NbExp=1; IntAct=EBI-34916, EBI-29075;
MiscellaneousPresent with 5240 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmPhosphorylated in case of disruption of sphingolipid synthesis. Phosphorylation regulates inhibitory activity of serine palmitoyltransferases (LCB1 and LCB2). {ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:19779198, ECO:0000269|PubMed:20182505}.
SimilarityBelongs to the ORM family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:20182505}; Multi- pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:20182505}.
SubunitComponent of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3. {ECO:0000269|PubMed:20182505}.