LMPD Database

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LMP007169

UniProt Annotations

Entry Information
Gene Namealkaline dihydroceramidase
Protein EntryYDC1_YEAST
UniProt IDQ02896
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionCatalyzes the conversion of dihydroceramide and also phytoceramide to dihydrosphingosine or phytosphingosine. Prefers dihydroceramide. Very low reverse hydrolysis activity, catalyzing synthesis of dihydroceramide from fatty acid and dihydrosphingosine. Is not responsible for the breakdown of unsaturated ceramide. May play a role in heat stress response.
InteractionP25376:AGP1; NbExp=1; IntAct=EBI-22203, EBI-2357; P08456:CHO1; NbExp=1; IntAct=EBI-22203, EBI-14055; P47133:EMC2; NbExp=1; IntAct=EBI-22203, EBI-25568; P39704:ERP2; NbExp=1; IntAct=EBI-22203, EBI-6587; P54837:ERV25; NbExp=1; IntAct=EBI-22203, EBI-6642; Q12361:GPR1; NbExp=1; IntAct=EBI-22203, EBI-7844; P47017:LSM1; NbExp=1; IntAct=EBI-22203, EBI-174; P32266:MGM1; NbExp=1; IntAct=EBI-22203, EBI-10865; P41543:OST1; NbExp=1; IntAct=EBI-22203, EBI-12651; P40975:PMP2; NbExp=1; IntAct=EBI-22203, EBI-2043041; Q04947:RTN1; NbExp=1; IntAct=EBI-22203, EBI-38020; P32368:SAC1; NbExp=1; IntAct=EBI-22203, EBI-16210; P39986:SPF1; NbExp=1; IntAct=EBI-22203, EBI-3128; Q02795:SWP1; NbExp=1; IntAct=EBI-22203, EBI-12666; P53751:YNR065C; NbExp=1; IntAct=EBI-22203, EBI-28557;
SimilarityBelongs to the alkaline ceramidase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.