LMPD Database

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LMP007201

UniProt Annotations

Entry Information
Gene NameATP-dependent RNA helicase DBP5
Protein EntryDBP5_YEAST
UniProt IDP20449
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + H(2)O = ADP + phosphate.
DomainThe Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
FunctionATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. Contributes to the blocking of bulk poly(A)+ mRNA export in ethanol-stressed cells. May also be involved in early transcription. {ECO:0000269|PubMed:10428971, ECO:0000269|PubMed:10523319, ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:11350039, ECO:0000269|PubMed:12192043, ECO:0000269|PubMed:12686617, ECO:0000269|PubMed:15280434, ECO:0000269|PubMed:15574330, ECO:0000269|PubMed:15619606, ECO:0000269|PubMed:9564047, ECO:0000269|PubMed:9564048}.
InteractionQ04839:GFD1; NbExp=2; IntAct=EBI-5617, EBI-27549; P50111:ZDS1; NbExp=3; IntAct=EBI-5617, EBI-29626;
MiscellaneousPresent with 14900 molecules/cell in log phase SD medium
MiscellaneousPresent with 14900 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the DEAD box helicase family. DDX19/DBP5 subfamily
SimilarityBelongs to the DEAD box helicase family. DDX19/DBP5 subfamily. {ECO:0000305}.
SimilarityContains 1 helicase ATP-binding domain
SimilarityContains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00541}.
SimilarityContains 1 helicase C-terminal domain
SimilarityContains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00542}.
Subcellular LocationCytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils. Accumulates in the nucleus rapidly and reversibly in response to ethanol stress.
SubunitAssociates with the nuclear pore complex. Interacts with NUP159, GLE1, GFD1 and ZDS1. The interaction with NUP159 is necessary for the association to the nuclear pore complex. Interacts also with the TFIIH complex subunits TFB1, TFB2 and RAD3. {ECO:0000269|PubMed:10428971, ECO:0000269|PubMed:10523319, ECO:0000269|PubMed:10610322, ECO:0000269|PubMed:12686617, ECO:0000269|PubMed:15574330, ECO:0000269|PubMed:15619606}.
Web ResourceName=RNA helicases from the baker's yeast Saccharomyces cerevisiae; URL="http://medweb2.unige.ch/~linder/RNA_helicases.html";