LMPD Database

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LMP007243

UniProt Annotations

Entry Information
Gene NameAtg21p
Protein EntryATG21_YEAST
UniProt IDQ02887
SpeciesYeast (S288c)
Comments
Comment typeDescription
DomainContains a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2).
DomainThe FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway and for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium and in both its recruitment to and dissociation from the PAS under starvation conditions.
FunctionRequired for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4- mediated cleavage. Essential for maturation of proaminopeptidase I. {ECO:0000269|PubMed:11536337, ECO:0000269|PubMed:11852075, ECO:0000269|PubMed:15155809, ECO:0000269|PubMed:15194695, ECO:0000269|PubMed:16876790, ECO:0000269|PubMed:18769150, ECO:0000269|PubMed:19793921, ECO:0000269|PubMed:20154084, ECO:0000269|PubMed:22108003}.
MiscellaneousPresent with 6020 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the WD repeat SVP1 family. {ECO:0000305}.
SimilarityContains 3 WD repeats. {ECO:0000305}.
Subcellular LocationCytoplasm. Vacuole. Note=And perivacuolar punctate structures.