LMPD Database

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LMP007313

UniProt Annotations

Entry Information
Gene NameErf2p
Protein EntryERFB_YEAST
UniProt IDQ06551
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionThe ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization. {ECO:0000269|PubMed:12193598}.
PtmAutopalmitoylated.
SimilarityBelongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. {ECO:0000305}.
SimilarityContains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:10490616, ECO:0000269|PubMed:12379641}; Multi- pass membrane protein {ECO:0000269|PubMed:10490616, ECO:0000269|PubMed:12379641}.
SubunitInteracts with SHR5. {ECO:0000269|PubMed:12193598, ECO:0000269|PubMed:12379641}.