LMPD Database

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LMP007453

UniProt Annotations

Entry Information
Gene NameNem1p
Protein EntryNEM1_YEAST
UniProt IDP38757
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
FunctionEssential for the formation of a spherical nucleus and meiotic division. Catalytic component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates SMP2. {ECO:0000269|PubMed:15889145, ECO:0000269|PubMed:9822591}.
InteractionP18410:SPO7; NbExp=4; IntAct=EBI-24435, EBI-17857;
MiscellaneousPresent with 377 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the Dullard family. {ECO:0000305}.
SimilarityContains 1 FCP1 homology domain. {ECO:0000255|PROSITE- ProRule:PRU00336}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:9822591}; Single-pass membrane protein {ECO:0000269|PubMed:9822591}. Nucleus membrane {ECO:0000269|PubMed:9822591}; Single-pass membrane protein {ECO:0000269|PubMed:9822591}.
SubunitComponent of the NEM1-SPO7 complex. {ECO:0000269|PubMed:9822591}.