LMPD Database

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LMP007544

UniProt Annotations

Entry Information
Gene NameD-sedoheptulose 7-phosphate isomerase
Protein EntryGMHA_ECOLI
UniProt IDP63224
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityD-sedoheptulose 7-phosphate = D-glycero-D- manno-heptose 7-phosphate. {ECO:0000269|PubMed:18056714}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
FunctionCatalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. {ECO:0000269|PubMed:11751812, ECO:0000269|PubMed:18056714}.
MiscellaneousThe reaction produces a racemic mixture of D- glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D- manno-heptose 7-phosphate.
PathwayBacterial outer membrane biogenesis; LPS core biosynthesis.
PathwayCarbohydrate biosynthesis; D-glycero-D-manno-heptose 7- phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7- phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Sequence CautionSequence=AAB08644.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the SIS family. GmhA subfamily. {ECO:0000305}.
SimilarityContains 1 SIS domain. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomotetramer. {ECO:0000269|PubMed:18056714}.