LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP007588

UniProt Annotations

Entry Information
Gene NameABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component
Protein EntryMLAB_ECOLI
UniProt IDP64602
SpeciesE. coli
Comments
Comment typeDescription
Disruption PhenotypeMutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269|PubMed:19383799}.
FunctionPart of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. {ECO:0000269|PubMed:19383799}.
Sequence CautionSequence=AAA57992.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 1 STAS domain. {ECO:0000255|PROSITE- ProRule:PRU00198}.
Subcellular LocationCytoplasm {ECO:0000305|PubMed:19383799}.
SubunitThe complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute- binding proteins (MlaB) and a periplamic solute-binding protein (MlaD). {ECO:0000305|PubMed:19383799}.