LMPD Database

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LMP007608

UniProt Annotations

Entry Information
Gene Namecrotonobetainyl CoA:carnitine CoA transferase
Protein EntryCAIB_ECOLI
UniProt IDP31572
SpeciesE. coli
Comments
Comment typeDescription
Catalytic Activity(E)-4-(trimethylammonio)but-2-enoyl-CoA + L- carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl- CoA.
Catalytic Activity4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA.
CautionWas originally thought to be an L-carnitine dehydratase. {ECO:0000305|PubMed:8188598}.
FunctionCatalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl- CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl- CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. {ECO:0000269|PubMed:11551212}.
InductionBy L-carnitine or crotonobetaine.
MiscellaneousSome strains of E.coli, such as ATCC 25922, can metabolize carnitine under aerobiosis.
PathwayAmine and polyamine metabolism; carnitine metabolism.
SimilarityBelongs to the CaiB/BaiF CoA-transferase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:15518548}.