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LMPD Database

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LMP007627

UniProt Annotations

Entry Information

Gene Name	ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein
Protein Entry	MLAE_ECOLI
UniProt ID	P64606
Species	E. coli

Comments

Comment type	Description
Disruption Phenotype	Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269\|PubMed:19383799}.
Function	Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. {ECO:0000269\|PubMed:19383799}.
Similarity	Belongs to the MlaE permease family. {ECO:0000305}.
Subcellular Location	Cell inner membrane {ECO:0000269\|PubMed:19383799}; Multi-pass membrane protein {ECO:0000269\|PubMed:19383799}.
Subunit	The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute- binding proteins (MlaB) and a periplamic solute-binding protein (MlaD). {ECO:0000305\|PubMed:19383799}.