LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP007664

UniProt Annotations

Entry Information
Gene NameOM lipoprotein stimulator of MrcB transpeptidase
Protein EntryLPOB_ECOLI
UniProt IDP0AB38
SpeciesE. coli
Comments
Comment typeDescription
Disruption PhenotypeMutant shows sensitivity to many beta- lactams. Absence of both LpoA and LpoB leads to a decrease in peptide cross-linking and to cell lysis. {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}.
FunctionRegulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Stimulates transpeptidase and transglycosylase activities of PBP1b in vitro. May also contribute to outer membrane constriction during cell division, in complex with PBP1b. {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}.
InteractionP02919:mrcB; NbExp=4; IntAct=EBI-3405489, EBI-909769;
SimilarityBelongs to the LpoB family. {ECO:0000305}.
Subcellular LocationCell outer membrane {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}; Lipid- anchor {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}; Periplasmic side {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}. Note=Localizes to the divisome and to the lateral wall.
SubunitInteracts with PBP1b. {ECO:0000269|PubMed:21183073, ECO:0000269|PubMed:21183074}.