LMPD Database

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LMP007686

UniProt Annotations

Entry Information
Gene NameABC transporter maintaining OM lipid asymmetry, ATP-binding protein
Protein EntryMLAF_ECOLI
UniProt IDP63386
SpeciesE. coli
Comments
Comment typeDescription
Disruption PhenotypeMutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane. {ECO:0000269|PubMed:19383799}.
FunctionPart of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for energy coupling to the transport system. {ECO:0000269|PubMed:19383799}.
InteractionP0A6F5:groL; NbExp=3; IntAct=EBI-561408, EBI-543750;
SimilarityBelongs to the ABC transporter superfamily. MlaF family. {ECO:0000305}.
SimilarityContains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular LocationCell inner membrane {ECO:0000305|PubMed:19383799}; Peripheral membrane protein {ECO:0000305|PubMed:19383799}; Cytoplasmic side {ECO:0000305|PubMed:19383799}.
SubunitThe complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute- binding proteins (MlaB) and a periplamic solute-binding protein (MlaD). {ECO:0000305|PubMed:19383799}.