LMPD Database

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LMP007693

UniProt Annotations

Entry Information
Gene Nametetraacyldisaccharide-1-P synthase
Protein EntryLPXB_ECOLI
UniProt IDP10441
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityUDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D- 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.
FunctionCondensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
InteractionP0CE47:tufA; NbExp=2; IntAct=EBI-553692, EBI-301077;
PathwayGlycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6.
SimilarityBelongs to the LpxB family. {ECO:0000305}.