LMPD Database

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LMP007761

UniProt Annotations

Entry Information
Gene Namephosphatidylglycerophosphatase C, membrane bound
Protein EntryPGPC_ECOLI
UniProt IDP0AD42
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityPhosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. {ECO:0000269|PubMed:21148555}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:21148555};
Disruption PhenotypeNo visible phenotype. Simultaneous deletion of pgpC and pgpA increases phosphatidylglycerophosphate (PGP) levels almost hundredfold relative to wild-type. In constrast, simultaneous deletion of pgpC and pgpB leads to a twofold increase of PGP levels. Lethal when combined with deletion of both pgpA and pgpB. {ECO:0000269|PubMed:21148555}.
FunctionLipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). {ECO:0000269|PubMed:21148555}.
PathwayPhospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.
Sequence CautionSequence=AAA79822.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA10910.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA51063.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Subcellular LocationCell inner membrane {ECO:0000269|PubMed:21148555}; Single-pass membrane protein {ECO:0000269|PubMed:21148555}.