LMPD Database

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LMP007788

UniProt Annotations

Entry Information
Gene NameProtein MBOA-6
Protein EntryMBOA5_CAEEL
UniProt IDO01925
SpeciesC. elegans
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=a; IsoId=O01925-1; Sequence=Displayed; Name=b; IsoId=O01925-2; Sequence=VSP_053557;
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine. {ECO:0000269|PubMed:18782225}.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. {ECO:0000269|PubMed:18782225}.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine. {ECO:0000269|PubMed:18782225}.
DomainThe di-lysine motif may confer endoplasmic reticulum localization. {ECO:0000250}.
FunctionProbable acyltransferase which may mediate the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3- phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn- glycero-3-phosphocholine or PC) (LPCAT activity). May also catalyze the conversion of lysophosphatidylethanolamine (1-acyl-2- hydroxy-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity), as well as the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Required for incorporation of arachidonic acid into PC, PE, and PS. {ECO:0000269|PubMed:18782225}.
PathwayLipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:18782225}.
SimilarityBelongs to the membrane-bound acyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000305}.