LMPD Database

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LMP007814

UniProt Annotations

Entry Information
Gene NameProtein ASM-2
Protein EntryQ23498_CAEEL
UniProt IDQ23498
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivitySphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ;
Developmental StagePreferentially expressed in post-embryonic development.
FunctionConverts sphingomyelin to ceramide.
MiscellaneousFully active upon secretion independent of zinc ions.
MiscellaneousThere are two types of sphingomyelinases: asm (acid), and nsm (neutral). Only acid sphingomyelinase has been found in worms. {ECO:0000250|UniProtKB:P17405, ECO:0000269|PubMed:9603947}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the acid sphingomyelinase family.
SimilarityContains 1 saposin B-type domain.
Subcellular LocationSecreted . Note=Only the secreted form is enzymatically active.