LMPD Database

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LMP007871

UniProt Annotations

Entry Information
Gene NameProtein HYL-1
Protein EntryHYL1_CAEEL
UniProt IDG5ED45
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + sphingosine = CoA + N- acylsphingosine. {ECO:0000269|PubMed:19372430}.
FunctionCatalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons. {ECO:0000269|PubMed:19372430}.
PathwayLipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:19372430}.
SimilarityBelongs to the sphingosine N-acyltransferase family. {ECO:0000305}.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.