LMPD Database

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LMP007883

UniProt Annotations

Entry Information
Gene NameProtein DLAT-1
Protein EntryQ19749_CAEEL
UniProt IDQ19749
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.
CofactorName=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Evidence= ; Note=Binds 1 lipoyl cofactor covalently. ;
FunctionThe pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
SimilarityBelongs to the 2-oxoacid dehydrogenase family.
SimilarityContains 1 lipoyl-binding domain.
Subcellular LocationMitochondrion matrix .