LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP007916

UniProt Annotations

Entry Information
Gene NameProtein LET-363
Protein EntryTOR_CAEEL
UniProt IDQ95Q95
SpeciesC. elegans
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=a; IsoId=Q95Q95-1; Sequence=Displayed; Name=b; IsoId=Q95Q95-2; Sequence=VSP_009223;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein.
Disruption PhenotypeDefects strongly increase lifespan, the mean lifetime being of 25 days instead of 10 days, suggesting that it may be involved in aging process. {ECO:0000269|PubMed:14668850}.
FunctionKinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May act as a mediator of lifespan regulation by insulin signaling and nutrient sensing. {ECO:0000269|PubMed:12225660, ECO:0000269|PubMed:14668850}.
SimilarityBelongs to the PI3/PI4-kinase family. {ECO:0000305}.
SimilarityContains 1 FATC domain. {ECO:0000255|PROSITE- ProRule:PRU00535}.
SimilarityContains 1 FAT domain. {ECO:0000255|PROSITE- ProRule:PRU00534}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 7 HEAT repeats. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:12225660}.
Tissue SpecificityUbiquitous. Expressed in all major tissues and organs, including the intestine, gonads and hypodermal cells. {ECO:0000269|PubMed:12225660}.