LMPD Database

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LMP008144

UniProt Annotations

Entry Information
Gene NameProtein SDHB-1
Protein EntrySDHB_CAEEL
UniProt IDQ09545
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivitySuccinate + a quinone = fumarate + a quinol.
CofactorName=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000250}; Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CofactorName=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137; Evidence={ECO:0000250}; Note=Binds 1 [3Fe-4S] cluster. {ECO:0000250};
CofactorName=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250}; Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
FunctionIron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). {ECO:0000250}.
PathwayCarbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Sequence CautionSequence=BAA23717.1; Type=Frameshift; Positions=4, 15, 28; Evidence={ECO:0000305};
SimilarityBelongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. {ECO:0000305}.
SimilarityContains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00465}.
SimilarityContains 1 4Fe-4S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00711}.
Subcellular LocationMitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
SubunitComponent of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit. {ECO:0000250}.