LMPD Database

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LMP008161

UniProt Annotations

Entry Information
Gene NameProtein H14E04.1
Protein EntrySTRM1_CAEEL
UniProt IDQ9TYP1
SpeciesC. elegans
Comments
Comment typeDescription
FunctionCatalyzes the methyl transfer from S-adenosyl-methionine to the C-4 of cholesterol and other sterols. May irreversibly shunt sterols away from dafachronic acid production. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. {ECO:0000269|PubMed:19531354}.
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family. {ECO:0000255|PROSITE-ProRule:PRU01022}.