LMPD Database

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LMP008216

UniProt Annotations

Entry Information
Gene NameProtein SIAH-1
Protein EntrySIAH1_CAEEL
UniProt IDQ965X6
SpeciesC. elegans
Comments
Comment typeDescription
DomainThe RING-type zinc finger domain is essential for ubiquitin ligase activity. {ECO:0000250}.
DomainThe SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family (By similarity). {ECO:0000250}.
FunctionE3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates (By similarity). {ECO:0000250}.
InteractionQ95Y80:bet-1; NbExp=2; IntAct=EBI-311877, EBI-311872;
PathwayProtein modification; protein ubiquitination.
Sequence CautionSequence=AAB94380.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the SINA (Seven in absentia) family. {ECO:0000305}.
SimilarityContains 1 RING-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00175}.
SimilarityContains 1 SIAH-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00455}.
SubunitInteracts with tir-1. {ECO:0000269|PubMed:15048112}.