LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP008341

Gene Information

Entrez Gene ID181445
Gene NameProtein SKR-20
Gene Symbolskr-20
SpeciesCaenorhabditis elegans
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0006511 IEA:InterProPubiquitin-dependent protein catabolic process
KEGG Pathway Links
KEGG Pathway IDDescription
cel04141Protein processing in endoplasmic reticulum
ko04141Protein processing in endoplasmic reticulum
M00380SCF-BTRC complex
cel_M00380SCF-BTRC complex
M00387SCF-FBW7 complex
cel_M00387SCF-FBW7 complex
M00381SCF-SKP2 complex
cel_M00381SCF-SKP2 complex
cel04350TGF-beta signaling pathway
ko04350TGF-beta signaling pathway
cel04120Ubiquitin mediated proteolysis
ko04120Ubiquitin mediated proteolysis
cel04310Wnt signaling pathway
ko04310Wnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
5653007AMER1 mutants destabilize the destruction complex
5653014APC truncation mutants are not K63 polyubiquitinated
5653015APC truncation mutants have impaired AXIN binding
5652842APC/C-mediated degradation of cell cycle proteins
5653016AXIN missense mutants destabilize the destruction complex
5653003AXIN mutants destabilize the destruction complex, activating WNT signaling
5652459Cell Cycle
5652458Cell Cycle, Mitotic
5653194Circadian Clock
5652960Cyclin A:Cdk2-associated events at S phase entry
5653389Cyclin D associated events in G1
5652479Cyclin E associated events during G1/S transition
5653002Degradation of beta-catenin by the destruction complex
5652494Disease
5653390G1 Phase
5652468G1/S Transition
5652469Mitotic G1-G1/S phases
5652841Regulation of APC/C activators between G1/S and early anaphase
5652843Regulation of mitotic cell cycle
5652466S Phase
5653010S33 mutants of beta-catenin aren't phosphorylated
5653011S37 mutants of beta-catenin aren't phosphorylated
5653012S45 mutants of beta-catenin aren't phosphorylated
5652959SCF(Skp2)-mediated degradation of p27/p21
5652930SCF-beta-TrCP mediated degradation of Emi1
5652608Signal Transduction
5653004Signaling by WNT in cancer
5652894Signaling by Wnt
5653013T41 mutants of beta-catenin aren't phosphorylated
5653008TCF7L2 mutants don't bind CTBP
5653017deletions in the AMER1 gene destabilize the destruction complex
5653018deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
5653009misspliced GSK3beta mutants stabilize beta-catenin
5653005phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
5653006truncated APC mutants destabilize the destruction complex
5653019truncations of AMER1 destabilize the destruction complex