LMPD Database

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LMP009044

UniProt Annotations

Entry Information
Gene Namemuscarinic Acetylcholine Receptor, A-type
Protein EntryACM1_DROME
UniProt IDP16395
SpeciesDrosophila
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=B; IsoId=P16395-1; Sequence=Displayed; Name=A; IsoId=P16395-2; Sequence=VSP_012002;
FunctionThe muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. May have a role in the processing of olfactory and mechanosensory signals; regulation of neurosecretion. {ECO:0000269|PubMed:2510174, ECO:0000269|PubMed:7550280}.
Sequence CautionSequence=AAA85449.1; Type=Frameshift; Positions=57; Evidence={ECO:0000305}; Sequence=ABF85716.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. E.coli genomic contaminant.; Evidence={ECO:0000305};
SimilarityBelongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. {ECO:0000255|PROSITE- ProRule:PRU00521}.
Subcellular LocationCell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Tissue SpecificityIntense staining in the glomeruli of the antennal lobes, the region of the nervous system containing terminals of antennal olfactory sensory neurons and mechanosensory neurons. Also a discrete group of neurosecretory cells in the pars intercerebralis of the brain. {ECO:0000269|PubMed:7550280}.