LMPD Database

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LMP009639

UniProt Annotations

Entry Information
Gene Namehydroxysteroid dehydrogenase 1
Protein EntryHSD1A_ARATH
UniProt IDP0DKC6
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityAn 11-beta-hydroxysteroid + NADP(+) = an 11- oxosteroid + NADPH. {ECO:0000269|PubMed:17074428}.
Developmental StageFirstly detected during early seed maturation, at 9 days after anthesis (DAA), peaking at 18 DAA, before falling sharply during late maturation. {ECO:0000269|PubMed:19542545}.
Disruption PhenotypeSemidwarf phenotype with reduced sensitivity to brassinosteroids (BRs) and enhanced sensitivity to abscisic acid (ABA) during germination. {ECO:0000269|PubMed:17616511}.
FunctionCatalyzes 11-beta, 17-beta-hydroxysteroid and reduces 17-beta-ketosteroids. Involved in regulating plant growth and development, probably promoting or mediating brassinosteroid effects. Plays a role during seed maturation. {ECO:0000269|PubMed:17074428, ECO:0000269|PubMed:17616511, ECO:0000269|PubMed:19542545}.
InductionBy brassinosteroids (BRs). Up-regulated by LEC2. {ECO:0000269|PubMed:17616511, ECO:0000269|PubMed:19542545}.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationLipid droplet. Membrane; Single-pass type II membrane protein.
Tissue SpecificityExpressed in the above-ground part of seedlings, especially in the vascular tissues. Also detected in the buds and silique pedicels. Highly induced in oil-accumulating tissues of maturing seeds. {ECO:0000269|PubMed:17616511, ECO:0000269|PubMed:19542545}.