LMPD Database

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LMP009666

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-3P 5-kinase-like
Protein EntryFAB1B_ARATH
UniProt IDQ9LUM0
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 3- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Disruption PhenotypeLeaf-curling phenotype. Root growth inhibition, root gravitropic response, and hyposensitivity to exogenous auxin. Fab1a and fab1b double mutant displays an abnormal vacuolar phenotype late in pollen development leading to inviable pollen (PubMed:19846542). {ECO:0000269|PubMed:19846542, ECO:0000269|PubMed:21173023, ECO:0000269|PubMed:21412048}.
FunctionThe PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). Plays an important role in maintenance of endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification processes. Required for development of viable pollen. Might mediate recycling of auxin transporters. {ECO:0000250, ECO:0000269|PubMed:19846542, ECO:0000269|PubMed:21173023, ECO:0000269|PubMed:21412048}.
SimilarityContains 1 FYVE-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00091}.
SimilarityContains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular LocationEndosome membrane {ECO:0000269|PubMed:21173023}; Peripheral membrane protein {ECO:0000269|PubMed:21173023}.
SubunitComponent of the PI(3,5)P2 regulatory complex at least composed of ATG18, SAC/FIG4, FAB1 and VAC14. {ECO:0000250}.
Tissue SpecificityUbiquitous with highest expression levels in the root hair zone, pollen, and stamens. {ECO:0000269|PubMed:19846542}.