LMPD Database

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LMP009713

UniProt Annotations

Entry Information
Gene Name3-ketodihydrosphinganine reductase-like protein
Protein EntryTC10A_ARATH
UniProt IDQ0WRJ2
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivitySphinganine + NADP(+) = 3-dehydrosphinganine + NADPH. {ECO:0000269|PubMed:21421810}.
Disruption PhenotypeHigh frequency of tricotyledons and altered flower morphology. The double mutants tsc10a and tsc10b are not viable. {ECO:0000269|PubMed:21421810}.
FunctionCatalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). Required for sphingolipid biosynthesis. In plants, sphingolipids seems to play a critical role in mineral ion homeostasis, most likely through their involvement in the ion transport functionalities of membrane systems in the root. Lacks stereospecificity and can also produce L-threo-DHS in addition to D-erythro-DHS. {ECO:0000269|PubMed:21421810}.
PathwayLipid metabolism; sphingolipid metabolism.
Sequence CautionSequence=AAF66134.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAO24564.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000305|PubMed:21421810}; Multi-pass membrane protein {ECO:0000305|PubMed:21421810}.
Tissue SpecificityExpressed in roots, leaves, stems, flowers and siliques. {ECO:0000269|PubMed:21421810}.