LMPD Database

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LMP010055

UniProt Annotations

Entry Information
Gene Namecyclin-dependent protein kinase inhibitor
Protein EntrySIM_ARATH
UniProt IDQ9LZ78
SpeciesArabidopsis
Comments
Comment typeDescription
Disruption PhenotypeMulticellular trichomes with nuclei showing reduced levels of endoreduplication. {ECO:0000269|PubMed:10952891, ECO:0000269|PubMed:11882294, ECO:0000269|PubMed:17098811, ECO:0000269|PubMed:17764505, ECO:0000269|PubMed:19717615, ECO:0000269|PubMed:20194967, ECO:0000269|PubMed:21558384}.
FunctionProbable cyclin-dependent protein kinase (CDK) inhibitor that functions as a repressor of mitosis in the endoreduplication cell cycle. Required for normal trichome endoreplicating cell cycles. {ECO:0000269|PubMed:10952891, ECO:0000269|PubMed:11882294, ECO:0000269|PubMed:17098811, ECO:0000269|PubMed:17764505, ECO:0000269|PubMed:19717615, ECO:0000269|PubMed:20194967}.
InductionDown-regulated by gibberellin. {ECO:0000269|PubMed:19576768}.
MiscellaneousPlants over-expressing SIM are dwarf with serrated leaves containing enlarged cells with increased levels of nuclear DNA. {ECO:0000305|PubMed:17098811}.
Subcellular LocationNucleus {ECO:0000269|PubMed:17098811}.
SubunitInteracts with CDKA-1, CYCD2-1, CYCD3-2 and CYCD4-1. {ECO:0000269|PubMed:17098811}.
Tissue SpecificityExpressed in the shoot apical meristem, leaf primordia and the elongation zone of the root. {ECO:0000269|PubMed:17098811}.