LMPD Database

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LMP010145

UniProt Annotations

Entry Information
Gene Namedihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex
Protein EntryODP23_ARATH
UniProt IDQ5M729
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.
CofactorName=(R)-lipoate; Xref=ChEBI:CHEBI:83088; Note=Binds 1 lipoyl cofactor covalently.;
FunctionThe pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). {ECO:0000269|PubMed:14764908}.
Sequence CautionSequence=AAD25602.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the 2-oxoacid dehydrogenase family. {ECO:0000305}.
SimilarityContains 1 lipoyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000269|PubMed:14671022}.