LMPD Database

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LMP011169

UniProt Annotations

Entry Information
Gene Name1-phosphatidylinositol-4-phosphate 5-kinase
Protein EntryFAB1C_ARATH
UniProt IDQ9SSJ8
SpeciesArabidopsis
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 3- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.
CautionLacks the FYVE domain, necessary to efficiently target the protein to membranes containing the phosphatidylinositol-3P substrate. Therefore, its molecular function remains unknown. {ECO:0000305}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
FunctionThe PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAL38344.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityContains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
SubunitComponent of the PI(3,5)P2 regulatory complex at least composed of ATG18, SAC/FIG4, FAB1 and VAC14. {ECO:0000250}.