LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP011383

UniProt Annotations

Entry Information
Gene Nametranscription factor MYC2
Protein EntryMYC2_ARATH
UniProt IDQ39204
SpeciesArabidopsis
Comments
Comment typeDescription
Disruption PhenotypeMinor effect on jasmonic acid response and no effect on glucosinolate biosynthesis, but decreased abscisic acid sensitivity. Myc2 and myc3 double mutant has an increased insensitivity to jasmonic acid. Myc2 and myc4 double mutant has an increased insensitivity to jasmonic acid. Myc2, myc3 and myc4 triple mutant has no jasmonate-related defense response, is devoid of glucosinolates and is extremely susceptible to generalist herbivores. {ECO:0000269|PubMed:12509522, ECO:0000269|PubMed:15208388, ECO:0000269|PubMed:21335373, ECO:0000269|PubMed:23943862}.
DomainThe C-terminal half contains an active nuclear localization signal (NLS). {ECO:0000269|PubMed:23169619}.
DomainThe JAZ-interaction domain (JID) (93-160) is sufficient for interaction with MYB proteins and most of the TIFY/JAZ proteins (PubMed:21335373 and PubMed:23943862).
DomainThe transcriptional activation domain (TAD) (149-188) overlaps with the destruction element (DE) (154-165). {ECO:0000269|PubMed:23593022}.
FunctionTranscriptional activator. Common transcription factor of light, abscisic acid (ABA), and jasmonic acid (JA) signaling pathways. With MYC3 and MYC4, controls additively subsets of JA- dependent responses. In cooperation with MYB2 is involved in the regulation of ABA-inducible genes under drought stress conditions. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the MYC recognition site (5'-CACATG-3'), and to the G-box (5'-CACNTG-3') and Z-box (5'-ATACGTGT-3') of promoters. Binds directly to the promoters of the transcription factors PLETHORA1 (PLT1) and PLT2 and represses their expression. Negative regulator of blue light-mediated photomorphogenic growth and blue- and far-red-light regulated gene expression. Activates multiple TIFY/JAZ promoters. Positive regulator of lateral root formation. Regulates sesquiterpene biosynthesis. Subjected to proteasome-dependent proteolysis. The presence of the destruction element (DE) involved in turnover is required for the function to regulate gene transcription. {ECO:0000269|PubMed:12509522, ECO:0000269|PubMed:15208388, ECO:0000269|PubMed:15923349, ECO:0000269|PubMed:21321051, ECO:0000269|PubMed:21335373, ECO:0000269|PubMed:21954460, ECO:0000269|PubMed:22669881, ECO:0000269|PubMed:23142764, ECO:0000269|PubMed:23593022, ECO:0000269|PubMed:23943862, ECO:0000269|PubMed:9368419}.
InductionDetected early after abscisic acid (ABA) treatment or after dehydration and high-salt stresses. Induced by UV treatment. Up-regulated by methyl jasmonate and herbivory. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15208388, ECO:0000269|PubMed:23593022, ECO:0000269|PubMed:23943862, ECO:0000269|PubMed:9368419}.
InteractionQ9LMA8:TIFY10A; NbExp=3; IntAct=EBI-1792336, EBI-1388539; Q9S7M2:TIFY10B; NbExp=2; IntAct=EBI-1792336, EBI-1792563; Q9LDU5:TIFY11A; NbExp=2; IntAct=EBI-1792336, EBI-2312095; Q9C9E3:TIFY11B; NbExp=2; IntAct=EBI-1792336, EBI-2312120; Q9M246:TIFY3A; NbExp=2; IntAct=EBI-1792336, EBI-2312209; Q9C5K8:TIFY3B; NbExp=2; IntAct=EBI-1792336, EBI-2312231; Q8LBM2:TIFY5A; NbExp=2; IntAct=EBI-1792336, EBI-2312143; Q9LVI4:TIFY6B; NbExp=5; IntAct=EBI-1792336, EBI-1792431; Q8W4J8:TIFY7; NbExp=3; IntAct=EBI-1792336, EBI-1792583; Q93ZM9:TIFY9; NbExp=2; IntAct=EBI-1792336, EBI-2312172;
PtmThe phosphorylation at Thr-328 is increased by methyl jasmonate treatment, facilitates the proteolysis of the protein and is coupled to transcription activity. {ECO:0000269|PubMed:23593022}.
Sequence CautionSequence=BAA25078.1; Type=Frameshift; Positions=353, 360; Evidence={ECO:0000305};
SimilarityContains 1 bHLH (basic helix-loop-helix) domain. {ECO:0000255|PROSITE-ProRule:PRU00981}.
Subcellular LocationNucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:15208388, ECO:0000269|PubMed:21335373, ECO:0000269|PubMed:23169619}.
SubunitHomo- and heterodimer. Efficient DNA binding requires dimerization with another bHLH protein (By similarity). Interacts (via N-terminus) with RGA, (via TAD domain) with the mediator subunit MED25, with TIC, MYC3, AFPH2/NINJA and the JAZ repressors TIFY10A/JAZ1, TIFY10B/JAZ2, TIFY6B/JAZ3, TIFY6A/JAZ4, TIFY11A/JAZ5, TIFY11B/JAZ6, TIFY5A/JAZ8, TIFY7/JAZ9, TIFY9/JAZ10, TIFY3A/JAZ11 and TIFY3B/JAZ12. Interacts with MYB28, MYB29, MYB34, MYB51, MYB76, MYB122 and mybe MYB2. {ECO:0000250, ECO:0000269|PubMed:19309455, ECO:0000269|PubMed:21321051, ECO:0000269|PubMed:21335373, ECO:0000269|PubMed:22669881, ECO:0000269|PubMed:22693280, ECO:0000269|PubMed:22822206, ECO:0000269|PubMed:23943862}.
Tissue SpecificityWidely expressed in the whole plant with the highest expression in stem. Constitutively expressed in dark- and light-grown seedlings. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:15923349}.