LMPD Database

LMP011526

UniProt Annotations

Entry Information
Gene NameNiemann-Pick disease, type C2
Protein EntryNPC2_DANRE
UniProt IDQ9DGJ3
SpeciesZebrafish
Comments
Comment typeDescription
FunctionIntracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. {ECO:0000250}.
SimilarityBelongs to the NPC2 family. {ECO:0000305}.
Subcellular LocationSecreted. Endoplasmic reticulum {ECO:0000250}.
SubunitInteracts with NUS1/NgBR, the interaction stabilizes NCP2 and regulates cholesterol trafficking. Interacts with DHDDS (By similarity). {ECO:0000250}.