LMPD Database

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LMP011907

UniProt Annotations

Entry Information
Gene Namemajor facilitator superfamily domain containing 2aa
Protein EntryNLS1A_DANRE
UniProt IDQ5U3U7
SpeciesZebrafish
Comments
Comment typeDescription
FunctionSodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega- 3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). {ECO:0000250}.
SimilarityBelongs to the major facilitator superfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.