LMPD Database

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LMP012241

UniProt Annotations

Entry Information
Gene Nameceramide-1-phosphate transfer protein
Protein EntryCPTP_DANRE
UniProt IDQ6DBQ8
SpeciesZebrafish
Comments
Comment typeDescription
FunctionMediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide (By similarity). {ECO:0000250}.
SimilarityBelongs to the GLTP family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.