LMPD Database

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LMP012279

UniProt Annotations

Entry Information
Gene Namespinster homolog 1 (Drosophila)
Protein EntrySPNS1_DANRE
UniProt IDQ7ZU13
SpeciesZebrafish
Comments
Comment typeDescription
Developmental StageExpressed both maternally and zygotically throughout embryogenesis, and also in adults. {ECO:0000269|PubMed:11836794}.
Disruption PhenotypePresence in early embryos of an opaque substance in the posterior yolk cell extension at approximately 1 day after fertilization. This material progressively accumulates and by 48 hours after fertilization fills the entire yolk. By day 3 of embryogenesis, embryos are severely reduced in size compared with their wild-type siblings and they die a few hours later. {ECO:0000269|PubMed:11836794, ECO:0000269|PubMed:18704191}.
FunctionSphingolipid transporter. {ECO:0000250}.
SimilarityBelongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. {ECO:0000305}.
Subcellular LocationMitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue SpecificityExpressed in yolk cells. {ECO:0000269|PubMed:11836794}.