LMPD Database

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LMP012312

UniProt Annotations

Entry Information
Gene Namesterol regulatory element binding transcription factor 2
Protein EntryA3KNA7_DANRE
UniProt IDA3KNA7
SpeciesZebrafish
Comments
Comment typeDescription
FunctionTranscriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity).
PtmAt low cholesterol the scap/srebp complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane (By similarity).
SimilarityBelongs to the SREBP family.
SimilarityContains 1 bHLH (basic helix-loop-helix) domain.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane ; Multi-pass membrane protein . Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
Subcellular LocationProcessed sterol regulatory element-binding protein 2: Nucleus {ECO:0000250|UniProtKB:Q12772, ECO:0000255|PROSITE-ProRule:PRU00981}.
SubunitForms a tight complex with scap in the ER membrane.