LMPD Database

LMP012344

Gene Information

Entrez Gene ID	4040
Gene Name	low density lipoprotein receptor-related protein 6
Gene Symbol	LRP6
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009986	IDA:BHF-UCL	C	cell surface
GO:0031410	IDA:BHF-UCL	C	cytoplasmic vesicle
GO:0005769	IEA:Ensembl	C	early endosome
GO:0005783	IEA:UniProtKB-KW	C	endoplasmic reticulum
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0043025	IBA:RefGenome	C	neuronal cell body
GO:0005886	IDA:BHF-UCL	C	plasma membrane
GO:0043235	IBA:RefGenome	C	receptor complex
GO:0045202	IBA:RefGenome	C	synapse
GO:0034185	IBA:RefGenome	F	apolipoprotein binding
GO:0071936	IDA:BHF-UCL	F	coreceptor activity involved in Wnt signaling pathway
GO:0005109	IPI:BHF-UCL	F	frizzled binding
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0019210	IMP:BHF-UCL	F	kinase inhibitor activity
GO:0005041	IDA:MGI	F	low-density lipoprotein receptor activity
GO:0042803	IPI:BHF-UCL	F	protein homodimerization activity
GO:0005102	IPI:BHF-UCL	F	receptor binding
GO:0019534	IMP:BHF-UCL	F	toxin transporter activity
GO:0042813	IBA:RefGenome	F	Wnt-activated receptor activity
GO:0017147	IPI:BHF-UCL	F	Wnt-protein binding
GO:0009952	IBA:RefGenome	P	anterior/posterior pattern specification
GO:0090245	IBA:RefGenome	P	axis elongation involved in somitogenesis
GO:0060349	IBA:RefGenome	P	bone morphogenesis
GO:0046849	IBA:RefGenome	P	bone remodeling
GO:0060444	IBA:RefGenome	P	branching involved in mammary gland duct morphogenesis
GO:0060070	IDA:UniProtKB	P	canonical Wnt signaling pathway
GO:0061310	IEA:Ensembl	P	canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
GO:0044335	IC:BHF-UCL	P	canonical Wnt signaling pathway involved in neural crest cell differentiation
GO:0061324	IEA:Ensembl	P	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0044340	IC:BHF-UCL	P	canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0042074	IEA:Ensembl	P	cell migration involved in gastrulation
GO:0071397	IMP:BHF-UCL	P	cellular response to cholesterol
GO:0021587	IBA:RefGenome	P	cerebellum morphogenesis
GO:0021795	IEA:Ensembl	P	cerebral cortex cell migration
GO:0021987	IBA:RefGenome	P	cerebral cortex development
GO:0060026	IBA:RefGenome	P	convergent extension
GO:0071542	IEA:Ensembl	P	dopaminergic neuron differentiation
GO:0048596	IBA:RefGenome	P	embryonic camera-type eye morphogenesis
GO:0042733	IEA:Ensembl	P	embryonic digit morphogenesis
GO:0035115	IEA:Ensembl	P	embryonic forelimb morphogenesis
GO:0035116	IEA:Ensembl	P	embryonic hindlimb morphogenesis
GO:0030326	IBA:RefGenome	P	embryonic limb morphogenesis
GO:0009880	IBA:RefGenome	P	embryonic pattern specification
GO:0060059	IBA:RefGenome	P	embryonic retina morphogenesis in camera-type eye
GO:0035261	IBA:RefGenome	P	external genitalia morphogenesis
GO:0060325	IBA:RefGenome	P	face morphogenesis
GO:0021861	IEA:Ensembl	P	forebrain radial glial cell differentiation
GO:0021943	IEA:Ensembl	P	formation of radial glial scaffolds
GO:0001702	IBA:RefGenome	P	gastrulation with mouth forming second
GO:0001947	IEA:Ensembl	P	heart looping
GO:0060596	IEA:Ensembl	P	mammary placode formation
GO:0030901	IBA:RefGenome	P	midbrain development
GO:0030917	IBA:RefGenome	P	midbrain-hindbrain boundary development
GO:0050680	IEA:Ensembl	P	negative regulation of epithelial cell proliferation
GO:0045599	IEA:Ensembl	P	negative regulation of fat cell differentiation
GO:2000151	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:2000162	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:2000168	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in neural tube closure
GO:2000164	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
GO:2000166	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
GO:2000149	IEA:Ensembl	P	negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
GO:0006469	IMP:BHF-UCL	P	negative regulation of protein kinase activity
GO:0001933	IMP:BHF-UCL	P	negative regulation of protein phosphorylation
GO:0071901	IDA:BHF-UCL	P	negative regulation of protein serine/threonine kinase activity
GO:0034392	IMP:BHF-UCL	P	negative regulation of smooth muscle cell apoptotic process
GO:0014033	IDA:BHF-UCL	P	neural crest cell differentiation
GO:0014029	IDA:BHF-UCL	P	neural crest formation
GO:0001843	IBA:RefGenome	P	neural tube closure
GO:0042475	IBA:RefGenome	P	odontogenesis of dentin-containing tooth
GO:0060021	IBA:RefGenome	P	palate development
GO:0003344	IBA:RefGenome	P	pericardium morphogenesis
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0045780	IEA:Ensembl	P	positive regulation of bone resorption
GO:0090263	IDA:BHF-UCL	P	positive regulation of canonical Wnt signaling pathway
GO:0045787	IMP:BHF-UCL	P	positive regulation of cell cycle
GO:0007204	IEA:Ensembl	P	positive regulation of cytosolic calcium ion concentration
GO:0002053	IEA:Ensembl	P	positive regulation of mesenchymal cell proliferation
GO:0045778	IEA:Ensembl	P	positive regulation of ossification
GO:0051091	IDA:BHF-UCL	P	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045893	IMP:BHF-UCL	P	positive regulation of transcription, DNA-templated
GO:0045944	IDA:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter
GO:2000055	IDA:BHF-UCL	P	positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0036342	IEA:Ensembl	P	post-anal tail morphogenesis
GO:0090009	IBA:RefGenome	P	primitive streak formation
GO:0090118	IBA:RefGenome	P	receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0060284	IEA:Ensembl	P	regulation of cell development
GO:0045598	IBA:RefGenome	P	regulation of fat cell differentiation
GO:0030278	IBA:RefGenome	P	regulation of ossification
GO:0051593	IEA:Ensembl	P	response to folic acid
GO:0043434	IEA:Ensembl	P	response to peptide hormone
GO:0016337	IEA:Ensembl	P	single organismal cell-cell adhesion
GO:0007268	IBA:RefGenome	P	synaptic transmission
GO:0021794	IBA:RefGenome	P	thalamus development
GO:1901998	IMP:GOC	P	toxin transport
GO:0060535	IBA:RefGenome	P	trachea cartilage morphogenesis
GO:0016055	IMP:BHF-UCL	P	Wnt signaling pathway
GO:0044332	IDA:BHF-UCL	P	Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0021874	IEA:Ensembl	P	Wnt signaling pathway involved in forebrain neuroblast division
GO:0090244	IBA:RefGenome	P	Wnt signaling pathway involved in somitogenesis

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04310	Wnt signaling pathway
ko04310	Wnt signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_200610	disassembly of the destruction complex and recruitment of AXIN to the membrane
REACT_116125	Disease
REACT_228096	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_200643	negative regulation of TCF-dependent signaling by WNT ligand antagonists
REACT_200716	regulation of FZD by ubiquitination
REACT_228188	RNF mutants show enhanced WNT signaling and proliferation
REACT_11045	Signaling by Wnt
REACT_228331	Signaling by WNT in cancer
REACT_111102	Signal Transduction
REACT_200777	TCF dependent signaling in response to WNT
REACT_228279	XAV939 inhibits tankyrase, stabilizing AXIN