LMPD Database

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LMP012390

UniProt Annotations

Entry Information
Gene Namealdehyde dehydrogenase 1 family, member A1
Protein EntryAL1A1_RAT
UniProt IDP51647
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityRetinal + NAD(+) + H(2)O = retinoate + NADH.
Enzyme RegulationInhibited by chloral hydrate.
FunctionIs capable of converting 9-cis and all-trans retinal to corresponding retinoic acid with high efficiency, 9-cis retinal being 2-fold more active than all-trans retinal.
PathwayCofactor metabolism; retinol metabolism.
PtmThe N-terminus is blocked.
SimilarityBelongs to the aldehyde dehydrogenase family
Subcellular LocationCytoplasm.
SubunitHomotetramer
Tissue SpecificityStrongly expressed in kidney, lung, testis, intestine, stomach, and trachea, but weakly in the liver.