LMPD Database

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LMP012453

UniProt Annotations

Entry Information
Gene Nameproteolipid protein 1
Protein EntryMYPR_RAT
UniProt IDP60203
SpeciesRat
Comments
Comment typeDescription
DiseaseNote=Defects in Plp1 are the causee of the dysmyelinating disease MD.
FunctionThis is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
SimilarityBelongs to the myelin proteolipid protein family
Subcellular LocationCell membrane; Multi-pass membrane protein. Myelin membrane . Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt- Lanterman incisures of myelin sheat