LMPD Database

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LMP012454

UniProt Annotations

Entry Information
Gene Namesteroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
Protein EntryS5A1_RAT
UniProt IDP24008
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative initiation; Named isoforms=2; Name=Long; IsoId=P24008-1; Sequence=Displayed; Name=Short; IsoId=P24008-2; Sequence=VSP_018884;
Biophysicochemical PropertiespH dependence: Optimally active at alkaline pHs.;
Catalytic ActivityA 3-oxo-5-alpha-steroid + NADP(+) = a 3-oxo- Delta(4)-steroid + NADPH.
Developmental StageAfter the establishment of chromosomal sex at fertilization.
FunctionConverts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
InductionIts expression is regulated by androgens such as testosterone.
SimilarityBelongs to the steroid 5-alpha reductase family
Subcellular LocationMicrosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue SpecificityLiver and prostate (at a low level).