LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP012458

UniProt Annotations

Entry Information
Gene Namecytochrome b5 reductase 3
Protein EntryNB5R3_RAT
UniProt IDP20070
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage, Alternative initiation; Named isoforms=3; Name=1; Synonyms=L-form reticulocyte reductase; IsoId=P20070-1; Sequence=Displayed; Note=Produced by alternative promoter usage.; Name=2; Synonyms=R-form reticulocyte reductase; IsoId=P20070-2; Sequence=VSP_009661; Note=Produced by alternative promoter usage.; Name=3; Synonyms=Soluble form; IsoId=P20070-3; Sequence=VSP_009660; Note=Produced by alternative initiation.;
Catalytic ActivityNADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
FunctionDesaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
PtmOnly the isoform 1 is myristoyled.
SimilarityBelongs to the flavoprotein pyridine nucleotide cytochrome reductase family
SimilarityContains 1 FAD-binding FR-type domain
Subcellular LocationIsoform 1: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side.
Subcellular LocationIsoform 3: Cytoplasm. Note=Produces the soluble form found in erythrocytes.
SubunitComponent of a complex composed of cytochrome b5, NADH- cytochrome b5 reductase (CYB5R3) and MOSC2
Tissue SpecificityIsoform 1 and isoform 3 are ubiquitously expressed. Isoform 2 is expressed only in erythroid tissues, reticulocytes and liver