LMPD Database

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LMP012467

UniProt Annotations

Entry Information
Gene Nameapolipoprotein A-I
Protein EntryAPOA1_RAT
UniProt IDP04639
SpeciesRat
Comments
Comment typeDescription
FunctionParticipates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
PtmGlycosylated
PtmPalmitoylated
PtmPhosphorylation sites are present in the extracellular medium
SimilarityBelongs to the apolipoprotein A1/A4/E family
Subcellular LocationSecreted.
SubunitInteracts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1 (By similarity)
Tissue SpecificityMajor protein of plasma HDL, also found in chylomicrons.