LMPD Database

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LMP012578

UniProt Annotations

Entry Information
Gene Nameglutathione peroxidase 4
Protein EntryGPX42_RAT
UniProt IDQ91XR8
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=Nuclear ; IsoId=Q91XR8-1; Sequence=Displayed; Name=Mitochondrial ; IsoId=P36970-1; Sequence=External; Name=Cytoplasmic; IsoId=P36970-2; Sequence=External; Note=Produced by alternative initiation at Met-28 of isoform Mitochondrial.;
Catalytic Activity2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O.
FunctionCould play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Stabilizes the condensed chromatin in sperm nuclei and is necessary male fertility (By similarity)
SimilarityBelongs to the glutathione peroxidase family
Subcellular LocationNucleus .