LMPD Database

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LMP012623

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 11, subfamily a, polypeptide 1
Protein EntryCP11A_RAT
UniProt IDP14137
SpeciesRat
Comments
Comment typeDescription
Catalytic ActivityCholesterol + 6 reduced adrenodoxin + 3 O(2) + 6 H(+) = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H(2)O
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
FunctionCatalyzes the side-chain cleavage reaction of cholesterol to pregnenolone
InductionInduced by FSH or pregnant mare's serum gonadotropin in ovaries of estrogen-treated immature rats in vivo.
PathwayLipid metabolism; C21-steroid hormone metabolism.
SimilarityBelongs to the cytochrome P450 family
Subcellular LocationMitochondrion membrane.
SubunitInteracts with FDX1/adrenodoxin
Tissue SpecificityExpressed in ovary, adrenal and testis