LMPD Database

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LMP012630

UniProt Annotations

Entry Information
Gene Namesphingosine-1-phosphate receptor 1
Protein EntryS1PR1_RAT
UniProt IDP48303
SpeciesRat
Comments
Comment typeDescription
Developmental StageFirst detected at embryonic day 15. At postnatal day 14 detected in skin, spleen, liver, kidney, heart, testicle, lung and brain. At adulthood is most abundant in brain
FunctionG-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity)
SimilarityBelongs to the G-protein coupled receptor 1 family
Subcellular LocationCell membrane ; Multi-pass membrane protein {ECO:0000250}. Endosome . Membrane raft . Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2- arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization (By similarity)
SubunitInteracts with GNAI1 and GNAI3