LMPD Database

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LMP012657

UniProt Annotations

Entry Information
Gene Namepiccolo (presynaptic cytomatrix protein)
Protein EntryPCLO_RAT
UniProt IDQ9JKS6
SpeciesRat
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9JKS6-1; Sequence=Displayed; Name=2; IsoId=Q9JKS6-2; Sequence=VSP_003930, VSP_003931; Name=3; IsoId=Q9JKS6-3; Sequence=VSP_018194;
DomainC2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change
FunctionMay act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking
InteractionQ920M9:Siah1; NbExp=2; IntAct=EBI-2271602, EBI-957514;
SimilarityContains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE- ProRule:PRU00143}.
SimilarityContains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCell junction, synapse. Note=Concentrated at presynaptic side of synaptic junctions.
SubunitInteracts with RABAC1/PRA1, RIMS2 and profilin