LMPD Database

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LMP012697

UniProt Annotations

Entry Information
Gene NameYKT6 v-SNARE homolog (S. cerevisiae)
Protein EntryYKT6_RAT
UniProt IDQ5EGY4
SpeciesRat
Comments
Comment typeDescription
DomainThe longin domain regulates palmitoylation and membrane targeting
FunctionVesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity
PtmFarnesylation is required for Golgi targeting.
PtmPalmitoylated; catalyzes its own palmitoylation. Palmitoylation is required for Golgi targeting (By similarity)
SimilarityBelongs to the synaptobrevin family
SimilarityContains 1 longin domain. {ECO:0000255|PROSITE- ProRule:PRU00231}.
SimilarityContains 1 v-SNARE coiled-coil homology domain
Subcellular LocationCytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes
SubunitIdentified in 2 different SNARE complexes; the first one composed of GOSR1, GOSR2 and STX5 and the second one composed of BET1L, GOSR1 and STX5.
Tissue SpecificityHighly expressed by neurons in brain and faintly detected in spleen, lung and kidney (at protein level). Ubiquitously expressed