LMPD Database

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LMP012732

Gene Information

Entrez Gene ID65248
Gene Nameprotein kinase, AMP-activated, alpha 1 catalytic subunit
Gene SymbolPrkaa1
SpeciesRattus norvegicus
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031588 IDA:UniProtKBCAMP-activated protein kinase complex
GO:0016324 IDA:UniProtKBCapical plasma membrane
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005634 ISS:UniProtKBCnucleus
GO:0043234 IDA:RGDCprotein complex
GO:0050405 IEA:UniProtKB-ECF[acetyl-CoA carboxylase] kinase activity
GO:0004679 IDA:UniProtKBFAMP-activated protein kinase activity
GO:0005524 IDA:RGDFATP binding
GO:0003682 ISS:UniProtKBFchromatin binding
GO:0042557 NAS:UniProtKBFeukaryotic elongation factor-2 kinase activator activity
GO:0035174 ISS:UniProtKBFhistone serine kinase activity
GO:0047322 IEA:UniProtKB-ECF[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0019900 IPI:RGDFkinase binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0008022 IPI:RGDFprotein C-terminus binding
GO:0004674 IDA:RGDFprotein serine/threonine kinase activity
GO:0050321 IEA:UniProtKB-ECFtau-protein kinase activity
GO:0000187 IEA:InterProPactivation of MAPK activity
GO:0006914 IEA:UniProtKB-KWPautophagy
GO:0071361 IEP:RGDPcellular response to ethanol
GO:0042149 ISS:UniProtKBPcellular response to glucose starvation
GO:0070301 IEP:RGDPcellular response to hydrogen peroxide
GO:0071456 IEP:RGDPcellular response to hypoxia
GO:0031669 ISS:UniProtKBPcellular response to nutrient levels
GO:0071417 IEP:RGDPcellular response to organonitrogen compound
GO:0006695 IEA:UniProtKB-KWPcholesterol biosynthetic process
GO:0009631 IDA:RGDPcold acclimation
GO:0006633 IEA:UniProtKB-KWPfatty acid biosynthetic process
GO:0055089 IDA:UniProtKBPfatty acid homeostasis
GO:0019395 IEA:EnsemblPfatty acid oxidation
GO:0042593 ISS:UniProtKBPglucose homeostasis
GO:0006006 IEA:EnsemblPglucose metabolic process
GO:0008610 ISS:UniProtKBPlipid biosynthetic process
GO:0043066 ISS:UniProtKBPnegative regulation of apoptotic process
GO:2001274 IMP:RGDPnegative regulation of glucose import in response to insulin stimulus
GO:0050995 ISS:UniProtKBPnegative regulation of lipid catabolic process
GO:0032007 ISS:UniProtKBPnegative regulation of TOR signaling
GO:0017148 NAS:UniProtKBPnegative regulation of translation
GO:0010508 ISS:UniProtKBPpositive regulation of autophagy
GO:0008284 IDA:RGDPpositive regulation of cell proliferation
GO:0046321 NAS:UniProtKBPpositive regulation of fatty acid oxidation
GO:0010628 IEA:EnsemblPpositive regulation of gene expression
GO:0045722 NAS:UniProtKBPpositive regulation of gluconeogenesis
GO:0046326 NAS:UniProtKBPpositive regulation of glucose import
GO:0045821 IDA:UniProtKBPpositive regulation of glycolytic process
GO:0051291 IDA:RGDPprotein heterooligomerization
GO:0006468 NAS:UniProtKBPprotein phosphorylation
GO:0042752 ISS:UniProtKBPregulation of circadian rhythm
GO:2000505 IDA:UniProtKBPregulation of energy homeostasis
GO:0006355 IEA:UniProtKB-KWPregulation of transcription, DNA-templated
GO:0060627 IMP:RGDPregulation of vesicle-mediated transport
GO:0014823 IDA:RGDPresponse to activity
GO:0031000 IDA:RGDPresponse to caffeine
GO:1901563 IEA:EnsemblPresponse to camptothecin
GO:0010332 ISS:UniProtKBPresponse to gamma radiation
GO:0009411 IEA:EnsemblPresponse to UV
GO:0048511 IEA:UniProtKB-KWPrhythmic process
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0016055 IEA:UniProtKB-KWPWnt signaling pathway
KEGG Pathway Links
KEGG Pathway IDDescription
ko04920Adipocytokine signaling pathway
rno04920Adipocytokine signaling pathway
ko04152AMPK signaling pathway
rno04152AMPK signaling pathway
ko04710Circadian rhythm
rno04710Circadian rhythm
rno04068FoxO signaling pathway
ko05410Hypertrophic cardiomyopathy (HCM)
rno05410Hypertrophic cardiomyopathy (HCM)
ko04910Insulin signaling pathway
rno04910Insulin signaling pathway
ko04150mTOR signaling pathway
rno04150mTOR signaling pathway
ko04932Non-alcoholic fatty liver disease (NAFLD)
rno04932Non-alcoholic fatty liver disease (NAFLD)
ko04921Oxytocin signaling pathway
rno04921Oxytocin signaling pathway
ko04151PI3K-Akt signaling pathway
rno04151PI3K-Akt signaling pathway
ko04140Regulation of autophagy
rno04140Regulation of autophagy
REACTOME Pathway Links
REACTOME Pathway IDDescription
5954019Energy dependent regulation of mTOR by LKB1-AMPK
5953430IGF1R signaling cascade
5953422Insulin receptor signalling cascade
5953428IRS-mediated signalling
5953425IRS-related events
5953429IRS-related events triggered by IGF1R
5953766mTOR signalling
5953432PI3K Cascade
5953733PKB-mediated events
5954018Regulation of AMPK activity via LKB1
5954161Regulation of Rheb GTPase activity by AMPK
5953423Signaling by Insulin receptor
5953431Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
5953381Signal Transduction